CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib
Identifieur interne : 001331 ( Main/Exploration ); précédent : 001330; suivant : 001332CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib
Auteurs : Guang-Ang Tian ; Chun-Chao Zhu ; Xiao-Xin Zhang ; Lei Zhu ; Xiao-Mei Yang ; Shu-Heng Jiang ; Rong-Kun Li ; Lin Tu ; Yang Wang ; Chun Zhuang ; Ping He ; Qing Li ; Xiao-Yan Cao ; Hui Cao ; Zhi-Gang ZhangSource :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Gastrointestinal stromal tumor (GIST) is the most major mesenchymal neoplasm of the digestive tract. Up to now, imatinib mesylate has been used as a standard first-line treatment for irresectable and metastasized GIST patients or adjuvant treatment for advanced GIST patients who received surgical resection. However, secondary resistance to imatinib usually happens, resulting in a major obstacle in GIST successful therapy. In this study, we first found that collagen and calcium binding EGF domains 1 (CCBE1) expression gradually elevated along with the risk degree of NIH classification, and poor prognosis emerged in the CCBE1-positive patients.
Url:
DOI: 10.1038/srep31071
PubMed: 27506146
PubMed Central: 4978997
Affiliations:
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China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Shanghai Medical College of Fudan University</institution>, Shanghai, 200032,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Zhu, Chun Chao" sort="Zhu, Chun Chao" uniqKey="Zhu C" first="Chun-Chao" last="Zhu">Chun-Chao Zhu</name><affiliation><nlm:aff id="a3"><institution>Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200127,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Xiao Xin" sort="Zhang, Xiao Xin" uniqKey="Zhang X" first="Xiao-Xin" last="Zhang">Xiao-Xin Zhang</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Zhu, Lei" sort="Zhu, Lei" uniqKey="Zhu L" first="Lei" last="Zhu">Lei Zhu</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Xiao Mei" sort="Yang, Xiao Mei" uniqKey="Yang X" first="Xiao-Mei" last="Yang">Xiao-Mei Yang</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Shu Heng" sort="Jiang, Shu Heng" uniqKey="Jiang S" first="Shu-Heng" last="Jiang">Shu-Heng Jiang</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. 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China</wicri:noCountry></affiliation></author><author><name sortKey="Tu, Lin" sort="Tu, Lin" uniqKey="Tu L" first="Lin" last="Tu">Lin Tu</name><affiliation><nlm:aff id="a3"><institution>Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200127,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Shanghai Medical College of Fudan University</institution>, Shanghai, 200032,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Zhuang, Chun" sort="Zhuang, Chun" uniqKey="Zhuang C" first="Chun" last="Zhuang">Chun Zhuang</name><affiliation><nlm:aff id="a3"><institution>Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200127,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Li, Qing" sort="Li, Qing" uniqKey="Li Q" first="Qing" last="Li">Qing Li</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation><affiliation><nlm:aff id="a2"><institution>Shanghai Medical College of Fudan University</institution>, Shanghai, 200032,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Cao, Xiao Yan" sort="Cao, Xiao Yan" uniqKey="Cao X" first="Xiao-Yan" last="Cao">Xiao-Yan Cao</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Cao, Hui" sort="Cao, Hui" uniqKey="Cao H" first="Hui" last="Cao">Hui Cao</name><affiliation><nlm:aff id="a3"><institution>Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200127,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author><author><name sortKey="Zhang, Zhi Gang" sort="Zhang, Zhi Gang" uniqKey="Zhang Z" first="Zhi-Gang" last="Zhang">Zhi-Gang Zhang</name><affiliation><nlm:aff id="a1"><institution>State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University</institution>, Shanghai, 200240,<country>P.R. China</country></nlm:aff><wicri:noCountry code="nlm country">P.R. China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Gastrointestinal stromal tumor (GIST) is the most major mesenchymal neoplasm of the digestive tract. Up to now, imatinib mesylate has been used as a standard first-line treatment for irresectable and metastasized GIST patients or adjuvant treatment for advanced GIST patients who received surgical resection. However, secondary resistance to imatinib usually happens, resulting in a major obstacle in GIST successful therapy. In this study, we first found that collagen and calcium binding EGF domains 1 (CCBE1) expression gradually elevated along with the risk degree of NIH classification, and poor prognosis emerged in the CCBE1-positive patients. <italic>In vitro</italic> experiments showed that recombinant CCBE1 protein can enhance angiogenesis and neutralize partial effect of imatinib on the GIST-T1 cells. In conclusion, these data indicated that CCBE1 may be served as a new predictor of prognosis in post-operative GIST patients and may play an important role in stimulating GIST progression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Joensuu, H" uniqKey="Joensuu H">H. Joensuu</name></author><author><name sortKey="Hohenberger, P" uniqKey="Hohenberger P">P. Hohenberger</name></author><author><name sortKey="Corless, C L" uniqKey="Corless C">C. L. 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Inacio</name></author><author><name sortKey="Belo, J A" uniqKey="Belo J">J. A. Belo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barton, C A" uniqKey="Barton C">C. A. Barton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gil Garcia, B" uniqKey="Gil Garcia B">B. Gil-García</name></author><author><name sortKey="Baladr N, V" uniqKey="Baladr N V">V. Baladrón</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crabtree, J S" uniqKey="Crabtree J">J. S. Crabtree</name></author><author><name sortKey="Singleton, C S" uniqKey="Singleton C">C. S. Singleton</name></author><author><name sortKey="Miele, L" uniqKey="Miele L">L. Miele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, J" uniqKey="Jiang J">J. 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Jiang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cao, Hui" sort="Cao, Hui" uniqKey="Cao H" first="Hui" last="Cao">Hui Cao</name><name sortKey="Cao, Xiao Yan" sort="Cao, Xiao Yan" uniqKey="Cao X" first="Xiao-Yan" last="Cao">Xiao-Yan Cao</name><name sortKey="He, Ping" sort="He, Ping" uniqKey="He P" first="Ping" last="He">Ping He</name><name sortKey="Jiang, Shu Heng" sort="Jiang, Shu Heng" uniqKey="Jiang S" first="Shu-Heng" last="Jiang">Shu-Heng Jiang</name><name sortKey="Li, Qing" sort="Li, Qing" uniqKey="Li Q" first="Qing" last="Li">Qing Li</name><name sortKey="Li, Rong Kun" sort="Li, Rong Kun" uniqKey="Li R" first="Rong-Kun" last="Li">Rong-Kun Li</name><name sortKey="Tian, Guang Ang" sort="Tian, Guang Ang" uniqKey="Tian G" first="Guang-Ang" last="Tian">Guang-Ang Tian</name><name sortKey="Tu, Lin" sort="Tu, Lin" uniqKey="Tu L" first="Lin" last="Tu">Lin Tu</name><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><name sortKey="Yang, Xiao Mei" sort="Yang, Xiao Mei" uniqKey="Yang X" first="Xiao-Mei" last="Yang">Xiao-Mei Yang</name><name sortKey="Zhang, Xiao Xin" sort="Zhang, Xiao Xin" uniqKey="Zhang X" first="Xiao-Xin" last="Zhang">Xiao-Xin Zhang</name><name sortKey="Zhang, Zhi Gang" sort="Zhang, Zhi Gang" uniqKey="Zhang Z" first="Zhi-Gang" last="Zhang">Zhi-Gang Zhang</name><name sortKey="Zhu, Chun Chao" sort="Zhu, Chun Chao" uniqKey="Zhu C" first="Chun-Chao" last="Zhu">Chun-Chao Zhu</name><name sortKey="Zhu, Lei" sort="Zhu, Lei" uniqKey="Zhu L" first="Lei" last="Zhu">Lei Zhu</name><name sortKey="Zhuang, Chun" sort="Zhuang, Chun" uniqKey="Zhuang C" first="Chun" last="Zhuang">Chun Zhuang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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